Found in all living cells, SAM e is also called activated methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAM e has undergone dozens of trials involving thousands of patients. Researchers studying the beneficial effects of SAM e have identified the following benefits of SAM e:
Liver
Detoxification
SAM e
metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent
enzymes (glutathione peroxidase and gluthathione-S -transferase),
which are important for liver function. Glutathione is necessary
for scavenging free radicals produced by glycolysis, the breakdown
of carbohydrates for energy. The amino acid taurine is another end
product of SAM e metabolism. The glutathione family of compounds
and taurine are important for liver detoxification reactions.
Brain
Function
SAM e
supports brain function by its methylation effects. Methylation
is the process by which a four aton appendage know as methyl group
(unit of one carbon and three hydrogen atoms) is transferred from
one moleculeto another. Of all methyl-donating substances known
in mammalian metabolism, SAM e is the most important. The donation
of methyl groups affects proper function of many metabolic processes
including brain function, energy production and DNA metabolism.
Neurotransmitters, substances involved in the brain's cell-to-cell
communication, are the products of substances in mammalian methylation
reactions. These compounds include L-dopa, dopamine, epinephrine
and phospatidyl choline (a component of lecithen).
Energy
Production
Methylation
form SAM e is critical for proper energy production as it converts
guanidinoacetate to creatine. Creatine metabolizes to creatine phospate,
which is important for recycling of ADP to ATP. Creatine maximizes
physical performance, reduces exercise fatigue and improves recovery
after exercise.
Longevity
Methyaltion
of DNA appears to be important in the prevention of DNA imperfections.
the demethylation of DNA is considered to be a contributor to the
aging process. Proper methylation through substances such as SAM e
positively influence longevity.
Because SAM e is a highly reactive molecule, it is very fragile. It degrades rapidly under conditions of high heat and/or humidity. Improper handling of SAM e can cause its degradation in a matter of hours, resulting in a loss of biological activity. This is why the manufacturing process for Jarrow Formulas® SAM e is done under low temperature and low humidity, and the table is enteric coated and blister-packed.
Pharmacokinetic studies show that oral supplementation of SAM e is most effective when enteric-coated by special gastric fluid-resistant polymers. Enteric coating SAM e results in maximum SAM e levels in the bloodstream.
Usage
and Safety
SAM e is extremely safe and suitable for long term supplementation.
The usual amount for continued use is 200 to 800 mg per day, the
higher level being taken before meals in divided doses. In clinical
trials, a loading dosage of 1,200 mg is sometimes used for three
weeks, and then a maintenance dosage of 400 to 800 mg per day is
followed.
Side effects are rare and appear to be limited to gastrointestinal disturbances. In some studies, there were actually more side effects among those using the placebo (inert/inactive compound given to the control subjects) than among those taking the SAM e.
The only contraindication that has been suggested to date is based upon theoretical concerns with no clinical instances found, and applies only to those with active clinical bipolor manic/depressive disorder.
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